The Scania R-series is a solid performer with a balanced approach across Safe Driving and Collision Avoidance. It is available with nearly all of the driver assistance systems Euro NCAP consider and they generally perform well, but many of those systems are additional cost options. The vision fundamentals are good, but the end result is limited by obstructions from conventional mirrors. The range benefits from a zero emission variant, which complies with Euro NCAP's post crash safety requirements. Overall, its a good option particularly for Highway operations, provided the appropriate options are selected.

The Scania R-series has a solid performance in safe driving. It has deep windows with a low belt line improving driver vision. However, the driver’s eyepoint is relatively high and vision is partially blocked by the use of conventional class II/IV mirrors. The optional camera monitor system improves front corner vision but duplicating a conventional mirror risks an increase in driver workload. A seat belt reminder is fitted on all seats, encouraging belt use. The attention assist system exceeds minimum legal requirements without excessive false alerts. A close following distance warning is not available. Use of the ACC reduces the risk of front into rear collision.

The Scania R-series has a range of crash avoidance technologies that generally perform well. It is equipped with an AEB system that is very good at avoiding collisions with other vehicles. An optional addition to the AEB is also good at avoiding frontal collisions with pedestrians and cyclists. An AEB system that prevents nearside collisions with cyclists is not available. Unintentional driver inputs during critical situations do not reduce system effectiveness. The system cannot be turned off easily and if turned off, automatically reactivates within 15 minutes. An optional lane support system is available, with limited lane keeping performance but a very good response in lane change conflicts.