The new Sprinter comes equipped as standard with all of the latest safety technology, and this performs extremely well in Euro NCAP's tests. The van's 2024 Platinum rating is a huge improvement on the previous version's 2023 Silver and the Sprinter now represents one of the best options for those van buyers looking for safety.Autonomous emergency braking (AEB) system is standard equipment throughout Europe. The system combines AEB with Forward Collision Warning (FCW) that detects vulnerable road users like pedestrians and cyclists as well as other vehicles. In Euro NCAP's tests of the system's reaction to vehicles, performance was good, tailing off only a little at higher speeds and where the target was offset to one side. Likewise, the system performed well in tests of its reaction to pedestrians and to cyclists.

The standard-fit Lane Support System (LSS) gently steers the vehicle if it is drifting out of lane and intervenes more aggressively in some more critical situations to prevent the van from leaving the road. A blind-spot information system is available.

The speed assistance system uses digital mapping and a camera to determine the local speed limit. This information is presented to the driver and the speed limiter can be set accordingly.

There is a standard-fit seatbelt reminder system for both the driver and passenger seat.